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    Sildenafil is used in the treatment of Erectile Dysfunction . Erectile dysfunction is the inability to achieve or maintain an erection long enough to perform sexual intercourse. Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope, tachycardia, postural hypotension, MI, cerebral thrombosis, cardiac arrest, paraesthesia, tremor, depression, herpes simplex, skin ulcer, oesophagitis, abnormal LFT, rectal haemorrhage, hypoglycaemic reaction, arthritis, deafness, retinal vascular disease, photosensitivity, accidental fall. Metabolism: Metabolised in the liver mainly by CYP3A4 and CYP2C9. Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil. Patients concurrently or intermittently using organic nitrates in any form. Excretion: Excreted as metabolites mainly in the faeces. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for c GMP degradation in the corpus cavernosum. Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Inhibition of PDE5 increases c GMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders. fluoxetine hydrochloride buy online Sildenafil citrate is the active ingredient in Viagra 50 MG Tablet, which is informally also known as the "blue pill". It is primarily used for the treatment of erectile dysfunction (ED), which is also called impotence, in men. Erectile dysfunction is a condition where a man is unable to achieve and/or maintain a penile erection adequate enough for sexual intercourse. It happens when there is a decreased blood flow to the penis. The decreased blood flow may be due to physical complications following an injury or disease or due to some psychological conditions such as anxiety, stress, depression, etc. Chronic lifestyle factors such as obesity, smoking, drinking, etc., could also contribute to ED. ED is strongly age-related, and the occurrence of moderate-to-severe ED could increase two-fold to three-fold between the ages of 40 and 70 years.

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