Treatments for breast cancer can increase the risk of bone thinning (called osteoporosis) or cause joint problems. This is because some treatments reduce the level of oestrogen, which helps keep bones strong. For example, chemotherapy can cause an early menopause, which reduces oestrogen. Some hormonal therapies cause a temporary or permanent menopause. Joint stiffness and pain are common side effects of aromatase inhibitor drugs (AIs). They reduce the risk of breast cancer coming back so it’s very important to keep taking them. Your doctor can prescribe drugs to control joint pain or change you to a different AI if you have difficult side effects. You will have a scan to check your bones before and sometimes during treatment with an AI. where can i buy prednisolone Hormone therapy is prescribed by a medical oncologist for women and men diagnosed with hormone receptor-positive breast cancer. It is prescribed to slow or stop the growth of hormone-sensitive tumors by blocking the body’s ability to produce hormones or by interfering with hormone action. When taken by women and men with early-stage breast cancers, it helps reduce the risk of getting a recurrence of the original breast cancer or getting a new primary breast cancer. Tamoxifen is a drug used to treat ER-positive early-stage breast cancer in premenopausal and postmenopausal women as well as in men. Tamoxifen is approved by the FDA and has been in wide use for over 30 years. Aromatase Inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and gynecomastia in men. They include Anastrozole (Arimidex), Letrozole (Femara), and Exemestane (Aromasin).. 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Could you describe your symptoms as such or is it definitely cramps.https:// only been on Tamoxifen for a year and I have such severe cramping all over my body... If I'am reading a book or magazine, my hands and digits will distort and I have to take my other hand and move it back in place. My toes, feet, calves, thighs, lower and mid back, stomach, neck and hands and fingers. When I yawn or sometimes when I brush my teeth my jaw will feel like I have lock jaw. Sometimes I can't sign my own name, it's terrible! I am suffering from vein thrombosis in my left leg on the inside of my knee right now. I have to definitely need to see my doctor, until now I didn't know that all my cramps were from this medicine. I have been on tamoxifen for a little over a year now. Both aromasin and tamoxifen can cause muscle and joint/bone pain. My GP has no idea either cuz I went many times to him complaining of all this. I am now experiencing severe muscle cramps in my upper thigh muscles in the evening on a fairly regular basis. Could not walk and could not straighten out my leg. Right now appear to have three side effects: tingling in my legs in the evening when I'm at rest; cold flashes every morning around 10 am and the severe leg cramps (which are getting worse). It is in the Vitamin section, it is a time release product and helps with the cramps but not muscle soreness. Was on tamoxifin 9 years from 1984-1993--never had cramping in my legs. The pain is nothing even close to what I used to call a "charlie horse". Have had blood tests and everything comes back perfect. They are so painful that they bring tears to my eyes because they are sooooo painful. Did you find something that worked to stop the severe cramping? It is suspect that I have fibromyalgia, hence the muscle soreness. 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