You should not use hydrochlorothiazide and metoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly. You should not use this medicine if you are unable to urinate. Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Hydrochlorothiazide and metoprolol is a combination medicine used to treat high blood pressure (hypertension). where can i buy kamagra jelly in london Not indicated for initial therapy; if fixed combination represents dose titrated to patient’s needs, therapy with combination may be more convenient than with separate components Lopressor HCT: metoprolol tartrate 50-100 mg and hydrochlorothiazide 25-50 mg PO daily in single or divided doses Dutoprol: metoprolol succinate 25-100mg and hydrochlorothiazide 12.5 mg PO q Day as a single dose When necessary, another antihypertensive agent may be added, beginning with 50% of usual recommended starting dose to avoid excessive fall in blood pressure To minimize dose-independent side effects, begin combination therapy only after patient fails to achieve desired effect with monotherapy Not indicated for initial therapy; if fixed combination represents dose titrated to patient’s needs, therapy with combination may be more convenient than with separate components Lopressor HCT: metoprolol tartrate 50-100 mg and hydrochlorothiazide 25-50 mg PO daily in single or divided doses Dutoprol: metoprolol succinate 25-100mg amd hydrochlorothiazide 12.5 mg PO q Day as a single dose When necessary, another antihypertensive agent may be added, beginning with 50% of usual recommended starting dose to avoid excessive fall in blood pressure To minimize dose-independent side effects, begin combination therapy only after patient fails to achieve desired effect with monotherapy May exacerbate ischemic heart disease following abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction occurrence after abrupt discontinuation When discontinuing chronically administered beta-blockers (particularly with ischemic heart disease) gradually reduce dose over 1-2 weeks and carefully monitor If angina markedly worsens or acute coronary insufficiency develops, reinstate beta-blocker administration promptly, at least temporarily (in addition to other measures appropriate for unstable angina) Warn patients against interruption or discontinuation of beta-blocker without physician advice Because coronary artery disease is common and may be unrecognized, slowly discontinue beta-blocker therapy, even in patients treated only for hypertension Anuria Cardiogenic shock CHF Heart block 2°/3° Hypersensitivity to either component or sulfonamides Overt cardiac failure Sick sinus syndrome (unless permanent pacemaker in place) Severe peripheral vascular disease Sinus bradycardia Anesthesia/surgery (myocardial depression); chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures Avoid abrupt withdrawal Acute transient myopia and acute angle-closure glaucoma has been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide) Bronchospastic disease Cerebrovascular insufficiency Cardiomegaly DM, fluid or electrolyte imbalance, hyperuricemia or gout, SLE Hyperthyroidism or thyrotoxicosis, liver disease May aggravate digitalis toxicity Peripheral vascular disease Pheochromocytoma Renal impairment Risk of male sexual dysfunction Sensitivity reactions may occur with or without history of allergy or asthma Metoprolol/hydrochlorothiazide is a fixed-combination tablet that combines a beta adrenergic receptor blocker, metoprolol tartrate (Lopressor HCT) or metoprolol succinate (Dutoprol) and a thiazide diuretic, hydrochlorothiazide Metoprolol is a beta-1-selective (cardioselective) adrenergic blocking agent at low doses; at higher doses, it also inhibits beta-2 adrenoreceptors in the bronchial and vascular smooth muscles While the mechanism of the antihypertensive effects of beta-blocking agents has not been elucidated, it may involve competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; a central effect leading to reduced sympathetic outflow to the periphery; and suppression of renin activity Hydrochlorothiazide is a thiazide diuretic that inhibits Na reabsorption in distal renal tubules resulting in increased excretion of Na and water, also K and H ions In comparison to immediate-release metoprolol (tartrate), the plasma metoprolol levels following administration of metoprolol succinate (long-acting) are characterized by lower peaks, longer time to peak and significantly lower peak to trough variation Bioavailability: 50% (metoprolol); (70%) hydrochlorothiazide Peak plasma concentration: 10-12 hr (metoprolol succinate); 2 hr (hydrochlorothiazide) Peak plasma time: 1.5-2 hr (metoprolol tartrate); 1.5-2.5 hr (hydrochlorothiazide) Onset: Initial diuresis from hydrochlorothiaizde (2 hr); antihypertensive effect: 3-4 days Duration: 3-6 hr (metoprolol tartrate); 6-12 hr (hydrochlorothiazide) Half-Life: 9-12 hr (metoprolol); 6-15 hr (hydrochlorothiazide) Clearance: hydrochlorothiazide 335 m L/min (hydrochlorothiazide) Excretion: Urine 95% (metoprolol) and 50-70% (hydrochlorothiazide) Dialyzable: No (hydrochlorothiazide) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Viagra doctors near me Where can i buy viagra in nairobi Lopressor HCT® metoprolol tartrate USP and hydrochlorothiazide USP 50/25 Tablets 100/25 Tablets 100/50 Tablets. Beta Blocker/Diuretic Antihypertensive. xanax 30mg Find patient medical information for Metoprolol Succinate-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, interactions, pictures. Metoprolol and Hydrochlorothiazide official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more. De werkzame stoffen in Metoprolol/Hydrochloorthiazide zijn metoprolol en hydrochloorthiazide. Metoprolol is sinds 1975 en hydrochloorthiazide sinds 1959 internationaal op de markt. Deze combinatie is onder de merknaam Selokomb op recept verkrijgbaar in tabletten met gereguleerde afgifte. De combinatie is ook verkrijgbaar als het merkloze Metoprolol/Hydrochloorthiazide. De combinatie van metoprolol met hydrochloorthiazide wordt gebruikt bij een hoge bloeddruk, als alleen een plasmiddel of alleen een bètablokker de bloeddruk niet voldoende naar beneden heeft gebracht. Metoprolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. 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