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However, a side effect of trazodone, orthostatic hypotension, which may cause dizziness and increase the risk of falling, can have devastating consequences for elderly patients; thus, this side effect, along with sedation, often makes trazodone less acceptable for this population, compared with newer compounds that share its lack of anticholinergic activity but not the rest of its side-effect profile. Still, trazodone is often helpful for geriatric patients with depression who have severe agitation and insomnia. zoloft symptoms It can be used alone or in combination with mood stabilizers such as lithium or valproate (e.g., Depakote). It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013, and is frequently prescribed for the treatment of major depressive disorder (MDD). It received regulatory approval in the United Kingdom in September 2014. 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Metoprolol is the generic form of the brand-name drug Lopressor. the generic form and under the brand names Lopressor and Toprol XL.