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    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Certain drugs may help improve ovarian activity in such women as metformin. Listing a study does not mean it has been evaluated by the U. Oral administration of metformin is accompanied by undesirable side effects. Polycystic ovary syndrome is a common cause of irregular periods, poor ovulation and delay in achieving pregnancy. The vagina proved to be a good alternative to the oral route for other drugs. Using metformin through the vagina and avoidance of such side effects, while maintaining its effectiveness, would help women to better tolerate this drug. PCOS is the most common of all female endocrinopathies affecting 7-10% of women. A variety of drugs have been used to help improve follicular dynamics in PCOS patients. Polycystic ovary syndrome (PCOS) is diagnosed in every tenth women at the age of over 18. It is one of the most common endocrine diseases of women of the reproductive age. However, according to the National Institutes of Health about 70% of women with this diagnosis do not even suspect any pathologies. There is an opinion about a role of the genetics and environment. But women who have had this disease maternally or paternally in the family are at a higher risk. Diabetes mellitus also increases a risk of this syndrome. About 70% of women with Polycystic Ovary Syndrome have a disorder of the response to insulin. This resistance (a reduced sensitivity) to insulin may lead to the development of diabetes mellitus type 2. One of the causes of PCOS is an insulin-resistance.

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