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    Estrace (Estrofem) on IVFPharmacy is made by Novo Nordisk Pharmaceuticals. The drug composition is exactly the same as Estrace in the US but the packaging may vary slightly. Here's how: US packaging: Estrace (Estrofem) is supplied in different quantities depending on the strength and type of box you buy. Estrace 1mg can be purchased in boxes of 10, 30 or 45. Estrace 2mg can be purchased in boxes of 30, 50 or 90. These symptoms are often caused by vulvar and vaginal atrophy (VVA). VVA is a condition caused by the loss of estrogen due to menopause—a tissue issue. While lubricants may help with the symptoms of mild VVA, they can't treat the underlying cause. Do not start using ESTRACE if you: have unusual vaginal bleeding, have or had certain cancers (including cancer of the breast or uterus), had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of the ingredients in ESTRACE vaginal cream, or think you may be pregnant. Tell your healthcare provider: if you are breastfeeding; about all of your medical problems, your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), migraine, endometriosis (including in women who have had a hysterectomy), lupus, problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood. ESTRACE vaginal cream should be used at the lowest dose possible for your treatment only as long as needed. Although ESTRACE vaginal cream is only used in and around the vagina, the risks associated with oral estrogens should be taken into account. The most common side effects include: headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and/or bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, vaginal burning, irritation and itching.

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