Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Pictures of plaquenil pills Difference between hydroxychloroquine Antimalarial drug hydroxychloroquine Plaquenil® is most likely to be effective in patients with dermatologic involve-ment, joint manifestations and hypercalcemia. Due to poten-tial macular toxicity, it is recommended that patients on hydroxychloroquine have an eye examination every 6-12 months. Methotrexate. Methotrexate is one of the most commonly I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Check the latest outcomes from 354,175 Methotrexate users, or browse all drugs. What is Plaquenil? Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Methotrexate plaquenil Hydroxychloroquine Plaquenil, Methotrexate or Plaquenil? DailyStrength Flomax and plaquenilDoes plaquenil reduce rheumatoid arthritisPlaquenil 200mg tablet costHuman anti-chimeric antibody rituximab hydroxychloroquineFang and hydroxychloroquine screening Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Methotrexate and plaquenil -. Methotrexate and Plaquenil drug interactions - eHealthMe. Methotrexate and hydroxychloroquine Rheumatoid Arthritis.. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. I know Plaquenil has helped me a ton, because I tried going off of it once to see if I really needed it. The first two weeks weren't bad, as Plaquenil has a high half-life and there was still some Plaquenil in my body. After that, my Lupus got progressively worse until I gave up and re-started the Plaquenil after 6 weeks of being off it. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications of RA.