Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine injection route Plaquenil and intestinal problems Plaquenil generic name Hydroxychloroquine is primarily a drug used to treat or prevent malaria. It is also used to treat symptomsof rheumatoid arthritis and discoid systemic lupus erythematosus. Malaria is a disease caused by parasites that enter the body. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Antimalarials such as hydroxychloroquine HCQ, are among the oldest prescribed drugs still used in clinical practice. Relatively inexpensive and well tolerated, these drugs have been recognized to be effective in autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythematosus SLE. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil medication type Plaquenil - Uses, Side Effects, Interactions -, Hydroxychloroquine Plaquenil Hydroxychloroquine erectile dysfunctionSides effects of hydroxychloroquinePlaquenil and mood changesPlaquenil causing tinnitus The two types of antimalarials most often prescribed today for lupus are hydroxychloroquine Plaquenil® and chloroquine Aralen®. Unlike the rapid response seen with steroids, it may take months before antimalarial drugs improve your lupus symptoms. Side effects from antimalarials are rare and usually mild. Medications used to treat lupus Lupus Foundation of America. A favorable effect of hydroxychloroquine on glucose and lipid.. Plaquenil Drug Information. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Prevents and treats malaria, and also treats a type of bowel infection. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for.