Downes sm hydroxychloroquine retinopathy

Discussion in 'Plaquenil Generic' started by killozon, 10-Mar-2020.

  1. rshop User

    Downes sm hydroxychloroquine retinopathy


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Plaquenil screening eye exam Chloroquine nail changes

    Hydroxychloroquine HCQ has been used for therapy of rheumatologic disorders since the 1950s. Ocular toxicity associated with HCQ use was initially described in the 1960s 1, 2. The incidence of HCQ retinopathy is estimated at 1 % after consumption of HCQ for 5 years. It is marked by paracentral and central scotoma and decreased color vision. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the 'flying saucer' sign. Downes SM. Hydroxychloroquine retinopathy. Eye 2017. How to set up a Hydroxychloroquine Retinopathy Screening Service. Yusuf IH, Luqmani R, Sharma SM, Downes SM. Hydroxychloroquine retinopathy an emerging problem. Eye Lond. 2017;2–6.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Downes sm hydroxychloroquine retinopathy

    Hydroxychloroquine - Wikipedia, Hydroxychloroquine retinopathy an emerging problem Eye

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  4. The estimated risk of hydroxychloroquine retinopathy in patients on chronic hydroxychloroquine therapy ranges from 0.4% to 8.0%. 1 Toxicity is thought to be dependent on cumulative total dose. 3 Additional factors that can precipitate early toxicity are concomitant renal disease and use of tamoxifen. 3.

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    Hydroxychloroquine retinal toxicity is far more common than previously considered; an overall prevalence of 7.5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20% after 20 years of treatment. This review aims to provide an update on HCQ/CQ retinopathy. We agreed with the conclusions of Latasiewicz et al 1 ‘Hydroxychloroquine retinopathy an emerging problem’, which cited cases of hydroxychloroquine HCQ-induced retinal damage. Three patients had received 400 mg HCQ daily for over 15 years equaling 4.93 mg/kg/day in two and 5.6 mg/kg/day in one and all developed maculopathies of varying severity. Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria.

     
  5. AndreM Well-Known Member

    Because scleroderma can take so many forms and affect so many different areas of the body, it can be difficult to diagnose. Anti-Malarial Medications - Scleroderma News Hydroxychloroquine Plaquenil Cellcept for scleroderma and lupus
     
  6. virusnix New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil and Depression/Anxiety - Symptoms and Medical. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis Plaquenil side effects of bipolar and depression Page 2
     
  7. axon New Member

    Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use.

    Plaquenil Guidelines Point Out New Risks, New Presentation.
     
  8. Mordawar Well-Known Member

    Treatment/Plaquenil - I completely agree with Lynnwood that plaquenil helps stop the progression of your disease, so the longer you wait the worse your Sjogren's becomes. Plaquenil is a fairly benign medication and was originally developed to protect against malaria. Later it was found to help autoimmune diseases. It can be months before you get relief with plaquenil.

    Sjogren's Syndrome Symptoms, Treatment, Diagnosis, & Diet