It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil fact sheet Pregnant plaquenil low platelts Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. I wonder if the commencement of the skin rashes and itching is related in some way to this decreased effectiveness of the medication too. So far from the other posts it may seems that Plaquenil may be somehow associated with skin rash that looks like small hives and patchy itchiness. Lupus is an inflammatory autoimmune disease that typically affects the joints and skin. Lupus of the skin often presents as a rash in the form of lesions, or as areas of red skin that resemble sunburn. Oral hydroxychloroquine and topical steroids are the mainstays of therapy for mild cutaneous lupus. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and face rash Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Terrible Itching on Plaquenil---PLEASE HELP. Plaquenil dosage per weight Yes with plaquenil generic, I have itching, intense I could scratch through my skin. But it does calm down. I also get weird rashes but I get those from the Lupus. I find the disease is being treated and the med is attacking the inflammation, so one of the first places inflammation shows up is the skin since it is the largest organ we have. Plaquenil and itching -. How to Treat and Prevent Lupus Rash Living with Cutaneous Lupus. Anyone Get An Itchy Rash From Plaquenil.. I got this after about 5 weeks, mine was a blistery rash and it was only on my shoulders, upper chest and upper back. My doctor said it was photodermatitis and caused from a sensitivity to the sun caused by the plaquenil. I had to off of Plaquenil in December after 2 months. I don't remember what the warnings were about the sun because I live in Michigan and we don't have much sun that time of year. One thing I would keep your eye on is if you develop a rash. I developed a rash on the back of my neck then all over my front from neck to pelvis area. Malar rash is a red or purplish facial rash with a “butterfly” pattern. It covers your cheeks and the bridge of your nose, but usually not the rest of the face.