Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. How many hours does plaquenil work in the body P62 chloroquine Both adults and children should take one dose of hydroxychloroquine per week starting at least 1 week. before traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. Children—Dose is based on body weight and must be determined by your doctor. At first, 13 mg per kg of body weight taken as a single dose. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil staggered dose Plaquenil hydroxychloroquine sulfate dosing, indications., Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine fertilityDoes hydroxychloroquine help with psoriatic arthritisIntravenous chloroquine injection In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. At the recommended dose, development of visual problems due to the medication is rare. Hydroxychloroquine Plaquenil. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Corticosteroids and salicylates may be used in conjunction with Plaquenil, and they can generally be decreased gradually in dosage or eliminated after a maintenance dose of Plaquenil has been achieved. How is Plaquenil Supplied. Plaquenil tablets are white, to off-white, film coated tablets imprinted “Plaquenil” on one face in black ink.