Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Most common side effects of hydroxychloroquine Test done before plaquenil Chloroquine phosphate resistant malaria Chloroquine phosphate reef2reef Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. What is plaquenil given for Hydroxychloroquine Plaquenil, Hydroxychloroquine - Wikipedia Chloroquine cell effect How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. Plaquenil Oral Uses, Side Effects, Interactions.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. It is not possible at the present time to explain precisely why hydroxychloroquine is effective in various rheumatic diseases. When effective, it can decrease damage to the tissues of the joints, skin and other organs in the body. How is Plaquenil Given? Hydroxychloroquine is a tablet that is best taken with food as it has a slightly bitter taste.