See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Plaquenil and hair color Plaquenil lowef platelets Medicine reactions between plaquenil and xolair We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Our original studies are referenced on 600+ peer-reviewed medical publications. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Aug 27, 2013 I saw him three weeks ago, and he encouraged me to try to taper down now that the plaquenil is helping so much. According to him, only doses lower than 3 mg per day can be considered to have zero long-term side effects, so he either wants me off the steroids completely, or to get at or below 3 mg. Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Which would you pick and why? - Plaquenil or Methotrexate, Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Plaquenil sanofiPlaquenil msdsChloroquine us brand nameHydroxychloroquine bone marrow suppression Buckley LM, Leib ES, Cartularo KS, et al. Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis. J Rheumatol 1997; 89. Ide M, Suzuki Y, Ichikawa Y, et al. Influence of long-term low-dose methotrexate therapy on periarticular and generalized osteoporosis in rheumatoid arthritis. Major side effects of low-dose methotrexate - UpToDate. Methotrexate vs. Long-Term Prednisone Lupus Forums at.. Does anyone take methotrexate and hydroxychloroquine. - NRAS. Some side effects of methotrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. I started methotrexate over a month ago because the plaquenil I have been on for over a year seemed to stop working for my joint pain. After trying several NSAIDS, my rheumie put me on low dose prednisone and added the methotrexate. I've read that methotrexate may not be good to take for the long term. Has anyone heard this? Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects.