In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil for joint pain in oeds Chloroquine phosphate for marine velvet Desorption of chloroquine and hydroxychloroquine from Sepia melanin. Initially 5 mg of melanin was saturated by equilibration with 5 mL of 1.9 mmol/L chloroquine prepared in 20 mM potassium phosphate buffer at pH 7.4 for 2 h. The samples were then centrifuged at 477 × g for 4 min and the supernatant removed. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. They were flat without induration or scaling. A diagnosis of HCQ-associated hyperpigmentation was made, and HCQ was discontinued. Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine skin pigmentation Discolored Skin Patches Pictures, Causes, and Treatments, Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Hydroxychloroquine 200 mg tab en espanolMalarone chloroquine resistance Skin itchiness, skin color changes, hair loss, and skin rashes. Chloroquine-induced itching is very common among black Africans 70%, but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. Chloroquine - Wikipedia. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. Changes of the skin and mucus membrane during the course of chloroquine therapy for connective tissue disorders. These female patients developed hyper pigmentation of the skin, largely on the exposed parts Chloroquine, hydrocychloroquine, amodiaquine and quinacrine are all example of antimalarials which can cause skin pigmentation. What does the skin pigmentation look like? Usually, when you start taking antimalarials, the areas of skin pigmentation which they can cause are small and oval in shape. As you take more antimalarials, the skin pigmentation will usually develop into large patches of discolouration. Jul 30, 2019 Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy.