If blood flow to these bone cells greatly decreases, the cells may die, causing the bone to collapse. Osteonecrosis can lead to pain, arthritis and limited use of affected joints. Some people may even need joint replacement surgery. Chloroquine and ciprofloxacin for typhoid prophylaxis Chloroquine diphosphate and penicillin Plaquenil and mouth sores Hydroxychloroquine hair loss Osteonecrosis, which is also called avascular necrosis AVN or aseptic necrosis, is the death of bone cells due to decreased blood flow. It can lead to pain and collapse of areas of bone. This collapse of bone, in turn, can lead to degenerative arthritis also called osteoarthritis of nearby joints, most often the hips and knees. Less often affected spots are the shoulders, hands and feet. Avascular necrosis AVN is a major cause of morbidity in SLE. Several factors have been associated with the development of osteonecrosis in SLE but corticosteroid therapy has been the most consistent. Many factors such as thromboembolism, fat embolism, thrombophilia, hypofibrinolysis, intramedullary haemorrhage, vasculitis and increased bone. Lupus can affect any part of the body, including the bones and bone tissue. Two especially common complications of lupus on the bones are osteoporosis and avascular necrosis. Osteoporosis is a condition in which the bones become less dense and more likely to fracture. Studies have found an increase. Less often affected spots are the shoulders, hands and feet. This can result in ulcers (sores) of gum tissue, exposed jaw bone and pain. Osteonecrosis, which is also called avascular necrosis (AVN) or aseptic necrosis, is the death of bone cells due to decreased blood flow. This collapse of bone, in turn, can lead to degenerative arthritis (also called osteoarthritis) of nearby joints, most often the hips and knees. Can plaquenil cause bone avascular Common and Rare Side Effects for Hydroxychloroquine Oral, Avascular necrosis of bone in systemic lupus erythematosus. What is a potential adverse effect of hydroxychloroquine plaquenilHydroxychloroquine for fibromyalgiaPlaquenil and methotrexate together Systemic lupus erythematosus SLE is an autoimmune rheumatic disease that affects young women, resulting in significant morbidity and mortality. Avascular necrosis of bone AVN is a well recognised complication of SLE, which also results in significant morbidity. Risk factors for avascular necrosis of bone in patients with.. How lupus affects the bones Lupus Foundation of America. A case of systemic lupus erythematosus presenting as.. Sep 27, 2018 Avascular necrosis and cancer. There are various types of drugs for conditions that weaken bones or cause bone loss and pain, such as arthritis. Drugs like Trexall and Plaquenil are used. Aug 02, 2017 These can cause the bone to collapse. Ultimately, the joint may break down and develop arthritis. The time between the first symptoms and the inability to move a joint varies. In general, it ranges from a few months to more than a year. Symptoms may appear bilaterally, meaning on both sides of the body. Low Blood Counts Due To Bone Marrow Failure; Low Blood Sugar; Low Levels Of A Type Of White Blood Cell Called Neutrophils; Low Levels Of White Blood Cells; Maculopathy; Mental Problems From Taking.