Plasmodium falciparum resistance to chloroquine

Discussion in 'Health Canada Drug Database' started by purple passion, 28-Feb-2020.

  1. 3ABTPAK XenForo Moderator

    Plasmodium falciparum resistance to chloroquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. Since the discovery of Plasmodium falciparum chloroquine CQ resistance transporter PfCRT and its role as the primary genetic determinant of chloroquine resistance CQR in P. falciparum, 53 distinct isoforms of this 424 amino acid protein have been found to be expressed in parasite isolates from around the globe 1–4. Where the person was infected what Plasmodium species is likely to be responsible and what drug is needed. P. falciparum and P. vivax have been confirmed to be resistant in some areas to many antimalarial drugs. For example, chloroquine resistant strain of P. falciparum has spread to most endemic areas.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Plasmodium falciparum resistance to chloroquine

    Chloroquine - FDA prescribing information, side effects and uses, Plasmodium falciparum chloroquine resistance transporter PfCRT.

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  6. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a.

    • Chloroquine Resistance in Plasmodium falciparum Malaria Parasites..
    • Plasmodium Falciparum - Malaria.
    • Plasmodium falciparum chloroquine resistance transporter is a H..

    Chloroquine is still a first-line antimalarial drug in uncomplicated falciparum malaria. Increasing resistance to chloroquine has been reported in many parts of Nigeria. Clinical and parasitological responses and classes of resistance to chloroquine in falciparum malaria in five communities in Delta region, southern Nigeria were assessed. Background Mutations in the chloroquine resistance transporter PfCRT change the susceptibility of Plasmodium falciparum to diverse antimalarial drugs. Results In addition to chloroquine, PfCRT transports quinine, quinidine, and verapamil, which bind to distinct but antagonistically interacting sites. The tremendous success of chloroquine and its heavy use through the decades eventually led to chloroquine resistance in Plasmodium falciparum and Plasmodium vivax the 2 parasite species responsible for most human malaria cases.

     
  7. voidedge Guest

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  8. prosei Guest

    Evidence continues to mount that some North American rheumatologists are not following practice recommendations for minimizing the retinal toxicity risk of patients on long-term hydroxychloroquine treatment. Plaquenil hydroxychloroquine sulfate dose, indications. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  9. stabilo Well-Known Member

    Chloroquine and Hydroxychloroquine Side Effects of. Keep chloroquine daily dose at 3 mg/kg/day and cumulative dose at 460 gm to reduce chances of retinopathy ; Keep hydroxychloroquine daily dose at 6.5mg/kg/day and cumulative dose at 1000gm to reduce chances of retinopathy ; Recognize that patients with renal failure are at unusually high risk of retinal toxicity

    Hydroxychloroquine toxicity - EyeWiki