Effect of chloroquine on liver enzymes

Discussion in 'Health Canada Drug Database' started by just.young.man, 06-Mar-2020.

  1. Ascorbinka XenForo Moderator

    Effect of chloroquine on liver enzymes


    Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress.

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    While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo. Chloroquine is active against the erythrocytic forms of Plasmodium vivax. Jul 30, 2019 Along with its needed effects, chloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine Incidence not known. Anxiety; attempts at killing oneself Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

    We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages.

    Effect of chloroquine on liver enzymes

    Chloroquine Side Effects Common, Severe, Long Term., Chloroquine Side Effects Common, Severe, Long Term -

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  7. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

    • Chloroquine - Wikipedia.
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    • Chloroquine - FDA prescribing information, side effects..

    The depressed activity of microsomal NADPH cytochrome c reductase was ameliorated by chloroquine. These results indicate that enzyme activities change independently of a change in phospholipid content in the subcellular organelles during ischemia. 6 The three enzyme activities remained depressed in the liver of the non-treated rat 24 h. In the case of 100 mg kg −1 day −1 the effect was highly significant compared with the other doses 10 and 30 mg kg −1 day −1. The results of the study revealed that α‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α‐Lipoic acid had a better protective effect when compared with silymarin, a. Jan 13, 1987 Chronic chloroquine treatment of miniature pigs resulted in increased activity of several lysosomal enzymes of the liver and brain. The most affected enzyme was alpha-fucosidase which showed a 3-fold increase in liver P less than 0.001 and a 2-fold increase in the brain P less than 0.01.

     
  8. Alex_soldier New Member

    , Hydroxychloroquine is widely used in the treatment of rheumatoid arthritis and systemic lupus erythematosus, with very few reported side‐effects. Plaquenil hydroxychloroquine 200mg is it causing itchy skin rash. I had a skin rash from plaquenil hydroxychloroquine. I was. Allergic reaction to plaquenil DailyStrength
     
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