Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Chloroquine how does it work Plaquenil and fever Chloroquine has two basic groups corresponding to the quinoline-ring nitrogen and the diethylamino side-chain nitrogen with ionization constants of 8.1 and 10.2, respectively 33–36. At a physiologic pH of 7.4, 18 % of chloroquine is monoprotonated but still soluble in lipid and able to traverse cell membranes. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin. Since Chloroquine is a weak base it has high affinity towards acidic lysosome. Chloroquine inhibits polymerase enzyme and interfere the formation of haemozoin and results in accumulation of toxic haeme and also it binds with haeme to form haeme- Chloroquine complex. Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Pharmacology of chloroquine Pharmacology of Chloroquine and Hydroxychloroquine Request PDF, Chloroquine mechanism of drug action and resistance in. Chloroquine regimen Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Hydroxychloroquine DermNet NZ. Chloroquine Pharmacology & Usage Details Medicine India. Chloroquine - DrugBank. Chloroquine - Clinical Pharmacology Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Pharmacology. Mechanism of Action Immune modulator. Chloroquine, an alkylated 4-aminoquinoline and analog of hydroxychloroquine, is an FDA-approved drug indicated for the treatment of malaria and extraintestinal amebiasis.