Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Information on plaquenil Doxycycline and plaquenil together Objectives To evaluate the efficacy and safety of 0.03% chloroquine phosphate eye drops in comparison with artificial tears for the treatment of dry eye syndrome. Ocular Surface Disease Index OSDI -a measure of symptom frequency. The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight. Malaria. Suppression — Adult Dose 500 mg = 300 mg base on exactly the same day of each week. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine phosphate eye drops Chloroquine Phosphate, Chloroquine Phosphate Manufacturers & Suppliers., Aralen Chloroquine Uses, Dosage, Side Effects. Hydroxychloroquine sulphate 200mgSide effects of plaquenil and methotrexate Ocular surface ecosystem modification with PROSE or Scleral lenses is increasingly being adapted for use in dry eye treatment. ARCHIVE Dry Eye Management and Therapy - Dry Eye Zone Forums. Chloroquine Indications, Side Effects, Warnings -. Chloroquine Phosphate 15-mg/mL Oral Liquid. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. If you are taking chloroquine phosphate for a long period of time, your doctor will recommend frequent eye exams. It is very important that you keep these appointments. Chloroquine phosphate can cause serious vision problems. If you experience any changes in vision, stop taking chloroquine phosphate and call your doctor immediately. New drugs for the treatment of dry eye disease William H Ridder III, Apoorva Karsolia Southern California College of Optometry, Marshall B Ketchum University, Fullerton, CA, USA Abstract Dry eye disease DED is one of the most commonly encountered conditions for eye care practitioners. The prevalence of DED can be as high as 30% of the population. In the past decade, only one drug has been.