Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine mice scratching What people lose their hair when on plaquenil Investigators at the University of Colorado are now reporting that adding the anti- malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize. Chloroquine CQ is a potent autophagy blocker and is the most widely investigated substance in this context. Previously, the effect of CQ has been demonstrated in a small randomized controlled trial in GBM treated with radiotherapy and carmustine. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. While there is considerable evidence for the efficacy and. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine clinical trials glioma Immunotherapy for Glioblastoma MD Anderson Cancer Center, The Addition of Chloroquine to Chemoradiation for Glioblastoma, Hydroxychloroquine 200 couponsPlaquenil prsivribed by rheumatilogshrs cut in halfHydroxychloroquine lupus side effectsAra patient information sheet hydroxychloroquineHydroxychloroquine poisoning Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas. Chloroquine for Treatment of Glioblastoma Multiforme - Full.. Frontiers Re-purposing Chloroquine for Glioblastoma.. Adding Chloroquine to Conventional Treatment for Glioblastoma.. Jun 10, 2017 METHODS AND ANALYSIS We describe a dose-finding phase Ib/II clinical trial, in which patients with IDH1/2-mutated chondrosarcoma, glioma and intrahepatic cholangiocarcinoma are treated with a combination of metformin and chloroquine. Dose escalation is performed according to a 3+3 dose-escalation scheme. Find clinical trials to treat adult glioblastoma. This phase II trial studies the side effects and how well low-dose whole-brain radiation therapy and temozolomide work in treating patients with newly diagnosed glioblastoma multiforme. This phase I clinical trial studies the side effects and best dose of oncolytic HSV-1 rQNestin34.5v.2 rQNestin34.5v.2 with or without cyclophosphamide in treating patients with malignant glioma that has come back recurrent. rQNestin34.5v.2 is a drug made from the herpes simplex virus type I, and if it is effective, may spread to a tumor cell, kill it, and then make a copy of itself and spread again.