Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine protein synthesis Chloroquine phosphate lupus Revised 10/2011 DAILY MEDICATION USE AND YOUR UPCOMING SURGERY PLEASE take time to thoroughly read this information. It is VERY IMPORTANT for you to know what medications you are taking and to understand what to do about your medications as your surgery date approaches. Osteonecrosis, which is also called avascular necrosis AVN or aseptic necrosis, is the death of bone cells due to decreased blood flow. It can lead to pain and collapse of areas of bone. This collapse of bone, in turn, can lead to degenerative arthritis also called osteoarthritis of nearby joints. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil nicotine Plaquenil Uses, Dosage & Side Effects -, Osteonecrosis Can plaquenil cause tirednessFda plaquenilPlaquenil and diarrheaChloroquine flatwormsHydroxychloroquine anti inflammatory HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of generic Plaquenil is around $18.60, 90% off the average retail price of $196.17. What is Plaquenil? - GoodRx. Hydroxychloroquine DermNet NZ. Can nicotine have effects on plaquenil? Yahoo Answers. Nicotine Major Nicotine has been reported to enhance the cardiovascular effects of adenosine receptor agonists; an increase in angina-like chest pain, heart rate, or a decrease in blood pressure may be noted. While no special cautions are recommended for regadenoson, it may be advisable for patients to avoid nicotine products or tobacco prior to electrophysiologic studies or stress testing where adenosine receptor agonists will be administered. Other oral medicines used in selected situations for this condition are the antimalarial hydroxychloroquine Plaquenil and the antibiotic metronidazole Flagyl, others. Immune response medicines Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember.