There are several drug categories such as: Mostly used for induction and/or maintenance therapy for patients with LN. Also used as first- or second-line and beyond therapy for patients with moderate/severe SLE Also used as third-line and beyond therapy for patients with mild SLEMainly used as third-line and beyond of treatment in patients with mild or moderate/severe SLE and LN Mainly used as alternative therapies to mycophenolate mofetil Can be used for induction therapy in refractory patients with LNAdd-on therapy in adult patients with active, autoantibody-positive SLE with a high degree of disease activity despite standard therapy Used as a third-line and beyond treatment for patients with moderate/severe SLE Used in a very small number of patients with mild SLE or LN Usually the treatment plan is based on your age, symptoms, organ involvement stage, and general health. Methylene blue falciparum target chloroquine Which is better for ra plaquenil or methotrexate Hydroxychloroquine suppress immune system Plaquenil Fatigue, joint pain Mild mostly GI symptoms, except for serious eye problems with chronic use at high dosages Antimalarial drug, frequently used to treat lupus and rheumatoid arthritis. Limited research on specific effectiveness in scleroderma. Imatinib mesylate Gleevec Skin fibrosis, pulmonary Moderate Anti-cancer drug. Many patients are prescribed plaquenil prior to developing symptoms. If patients are prescribed HCQ early in the disease process then they could be taking the drug for many years. The standard dose for a new patient prescribed plaquenil is 200 mg BID. Is this too much? 2011 Guidelines warned about cumulative dose of 1000g Plaquenil is a drug routinely prescribed for rheumatoid arthritis and lupus. Plaquenil has long been associated with retinal toxicity which can lead to vision loss. In particular it affects the macular region of the retina which is responsible for central vision. In many cases it will take some time (several months or even years) to reach the best treatment for your specific condition and keep your lupus under control. The goals of a treatment plan are to reduce inflammation, reduce organ damage, suppress the over-activity of your immune system, prevent flares, and relieve your symptoms. Plaquenil standard of care Despite Plaquenil dosing recommendations, retinal toxicity., PowerPoint. Update on Plaquenil Testing Natural substitute for plaquenil for discoid lupusCan you abruptly stop hydroxychloroquineHydroxychloroquine bleaching creamSynthesis of chloroquine from 4 7 dichloroquinoline Macular Society Eye screening for patients taking hydroxychloroquine. Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation. Eye screening for patients taking hydroxychloroquine Plaquenil. Plaquenil Examination - McKinney Eye Works. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Mar 01, 2011 Hydroxychloroquine Plaquenil, Sanofi-Aventis remains widely used in the treatment of various rheumatologic disorders. A small percentage of patients exposed to hydroxychloroquine will develop irreversible, and potentially progressive, retinal toxicity for which no effective treatment exists. In this retrospective study, the effect of hydroxychloroquine HCQ added to maintenance therapy according to the standard of care SoC was evaluated for 1 year in 101 patients with systemic lupus erythematosus SLE. Methods. The primary endpoint was the SLE Disease Activity Index SLEDAI. New Insights into Hydroxychloroquine Plaquenil Retinotoxicity. Two new articles1, 2 further refine our understanding of the retinotoxic risks of Plaquenil usage, and also provide new insights into patient evaluation and follow-up care. It is well understood that hydroxychloroquine HCQ has the potential to cause irreversible central vision loss.