Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil visual field coding Plaquenil and puffy face Plaquenil dosing for ra Mar 10, 2017 Although drug cessation, partly due to long half-life of the drug, does not always arrest progression of toxicity, it can limit the extent of structural and functional deficits and reduce the risk. Our prevalence data apply to the overall population of long-term hydroxychloroquine users, and risk rises markedly after 10 years of use. However, in rheumatologic practices, many patients benefit from the use of the drug for much longer periods, and it is important to know the annual risk as they stay on the drug regimen. Progression of Hydroxychloroquine Toxic Effects After Drug Therapy Cessation New Evidence From Multimodal Imaging. and long-term follow-up of patients with hydroxychloroquine retinopathy. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Long-term progression of hydroxychloroquine retinopathy off the drug marmor AMERICAN COLLEGE OF RHEUMATOLOGY, The Risk of Toxic Retinopathy in Patients on Long-term. Chloroquine drug 13000Side effects from plaquenil on eye Aug 30, 2011 The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmol 2014;153–60. Wolfe F, Marmor MF Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Progression of Hydroxychloroquine Toxic Effects After Drug.. Monitoring for hydroxychloroquine retinopathy Eye. One study identified the utility of monitoring tests to detect progression in patients diagnosed with hydroxychloroquine retinopathy 13 to 40 months after the drug was discontinued. Concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Monitoring Guidelines. Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002. Oct 16, 2014 Hydroxychloroquine is often prescribed as long-term therapy for many dermatologic indications, and it may have broader benefits e.g. preventing or improving thrombophilia associated with lupus erythematosus, neonatal lupus erythematosus, diabetes in rheumatoid arthritis and other connective tissue diseases, and as adjunctive therapy in some cancers.