Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Symptoms of eye side effects from plaquenil Aralen and water Hydroxychloroquine ingredients Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Taking methotrexate with hydroxychloroquine has not been studied. It may increase your risk of side. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and methotrexate Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center, Effects of methotrexate and hydroxychloroquine combination therapy vs. Is hydroxychloroquine the same as plaquenilHow long can you stay on plaquenilAralen instructionsPlaquenil treatment 1cd 10 Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Hydroxychloroquine Side-effects, uses, time to work. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Methotrexate and Coronavirus Apologies if this. - LUPUS UK. Compare Hydroxychloroquine vs. Methotrexate, which is better for uses like RA, Lupus and Arthritis. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral.