Patients starting chloroquine (CQ) or hydroxychloroquine (HCQ; i.e. Plaquenil) should have a baseline examination that serves as a reference point, as well as to rule out any preexisting maculopathies. Im chloroquine Chloroquine inhibitor Chloroquine phosphate and prime Can plaquenil cause swelling Mar 17, 2017 Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. This update is in response to the fact that new information is continually being uncovered regarding Plaquenil toxicity and testing for Plaquenil toxicity. The primary objective of this paper is to highlight the fact that the levels needed to achieve toxicity are related to the status of functioning of the liver and kidneys which work to clear the drug. The study was a Kaiser Permanente retrospective case-control study that examined 2361 patients who had used hydroxychloroquine continuously for at least 5 years according to pharmacy records and who were evaluated with visual field testing or spectral-domain optical coherence tomography. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine (Plaquenil) and chloroquine to account for the many studies that have shown the effects of these medications on the retina (1). While most rheumatologists are now routinely prescribing their patients 400 mg of HCQ (or 250 mg CQ) daily for the management of conditions like systemic lupus erythematosus and rheumatoid arthritis, individuals of short stature often have their dosage determined off of their ideal body weight to avoid overdosing. Plaquenil testing review of optometry Hydroxychloroquine Plaquenil Toxicity and., Hydroxchloroquine and Chloroquine Toxicity - Eye Lessons How long does it take for plaquenil to take effectChloroquine over the counter uk Dr. Corte provides a quick reference guide based on the AAO's updated screening guidelines for chloroquine and hydroxychloroquine Plaquenil retinopathy. As optometrists, it is important that we are aware of the possible ocular complications that can occur from the use of high risk medications. Quick Reference Screening for Chloroquine.. My Take on New Ocular Screening Guidelines for Plaquenil.. Early Plaquenil Toxicity Detected. - School of Optometry. Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Because “the risk of toxicity after years of Plaquenil use is higher than previously believed,” the study says. 1 Also, better objective testing equipment has been developed since the previous guidelines were released in 2002, so it’s more important than ever to screen for early changes—and the earlier, the better.