While it comes with a whole host of unpleasant side effects, it has the highest rate of continued long-term treatment. fit=300,270&ssl=1" class="alignleft size-full wp-image-520" src="https://i1com/ resize=300,270&ssl=1" alt="methotrexate" width="300" height="270" data-recalc-dims="1" /However methotrexate is a double edged sword. In short, the side effects are worth it to most people, because it reduces their joint pain and inflammation effectively. Most people who take the drug see it as a necessary evil. Plaquenil vision effects Chloroquine long term side effects Calcium chloroquine tcr Hydroxychloroquine myositis Early, aggressive disease management is critical for halting disease progression and joint destruction in patients with rheumatoid arthritis. Combination therapy with at least two disease-modifying antirheumatic drugs, such as methotrexate MTX, sulfasalazine, or hydroxychloroquine, is often more effective than monotherapy in reducing disease. Its efficacy is similar to that of methotrexate, but the choice of sulfasalazine may be made if the patient is a heavy drinker, or may become pregnant. It is sometimes prescribed by itself or maybe prescribed in combination with hydroxychloroquine Plaquenil or with methotrexate, it usually takes 6-12 weeks to start to feel the benefits. What are the side effects of hydroxychloroquine and sulfasalazine in treating rheumatoid arthritis? ANSWER Hydroxychloroquine Plaquenil and sulfasalazine Azulfidine are used for mild. The body can adjust, particularly if the drug dose is tapered up slowly. Some people don’t experience side effects at all, but most experience some discomfort at least. For most people, the side effects will fade over time. Hydroxychloroquine and sulfasalazine combination Treatment of rheumatoid arthritis with methotrexate and., Sulfasalazine - Medications for Rheumatoid Arthritis RA Hydroxychloroquine lupus dosePlaquenil skin changesHydroxychloroquine screening testSulfasalazine and hydroxychloroquine O’Dell JR et al. 2002 “Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial” Arthritis Rheum May;4651164-70. Hydroxychloroquine Plaquenil RheumTutor. What are the side effects of hydroxychloroquine and.. DMARDs Arthritis Foundation. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Rheumatoid arthritis is no longer as disabling a condition as it was in the past, thanks in large part to combination therapy - taking more than one RA medicine at a time. Doing so can lessen. Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just wondered how other people got on with it.