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    Hydroxychloroquine-Induced Retinal Toxicity - American Academy of. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful.

    Chloroquine And Hydroxychloroquine Toxicity - StatPearls.