Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance. Plaquenil sideceffects Pool chloroquine tablet Used to treat malaria infections Quinine This drug inhibits DNA synthesis Chloroquine This drug antiprotozoan drug damages DNA Metronidazole This antihelminthic drug is used for infections of worms Praziquantel This antihelminthic drug works by paralyzing the worm allowing the body to be excrete Praziquantel Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. In addition, any of the regimens listed for the treatment of chloroquine-resistant malaria may be used for the treatment of chloroquine-sensitive. P. falciparum. malaria. Prompt initiation of an effective regimen is vitally important, so using any one of the effective regimens that is readily available would be the preferred strategy. Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II . These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2]. Chloroquine-resistant malaria may be treated with quizlet How Malaria Is Treated - Verywell Health, Chloroquine - Wikipedia Hydroxychloroquine 400 mg tabletsAao plaquenil pppPlaquenil reduces preeclampsiaHydroxychloroquine 200 mg acetaminophen 400 mgArtemisinin and chloroquine structure Chloroquine does not treat the hypnozoite liver stage forms of Plasmodium and will therefore not prevent relapses of malaria due to P. vivax or P. ovale. Additional treatment with an anti-malarial agent active against these forms, such as an 8-aminoquinoline, is required for the treatment of infections with P. vivax and P. ovale. Chloroquine - FDA prescribing information, side effects and uses. Treatment of Malaria Guidelines for Clinicians United.. Chloroquine plus proguanil chloroquine malaria. In special circumstances and after consultation with malaria experts available through the CDC Malaria Hot-line 770-488-7100, primaquine may be used for prophylaxis for travel to areas with or without chloroquine-resistant P. falciparum Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. In areas with chloroquine-resistant P falciparum, quinine sulfate, mefloquine, or atovaquone/proguanil is suggested. Because these chemoprophylaxis agents do not eliminate P vivax and P ovale forms of the parasite that remain in the liver, primaquine phosphate treatment is recommended when living in endemic areas.