Chloroquine maculopathy dose

Discussion in 'Canadian Pharcharmy' started by mage, 05-Mar-2020.

  1. Tier Guest

    Chloroquine maculopathy dose


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Retinopathy, maculopathy, irreversible retinal damage, as well as macular degeneration have been reported. Retinopathy from chloroquine may be dose related. Initial and periodic eye examinations are recommended during prolonged treatment. Chloroquine should be discontinued immediately if there are changes in vision. The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Recent data have highlighted that hydroxychloroquine retinopathy is more common than previously reported. The prevalence in long term use patients appears to be around 7.5% and depending on dose and duration of therapy can increase to 20-50% after 20 years of therapy. Risk increases for patients taking more than 5mg/ kg/day.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine maculopathy dose

    Drug induced maculopathy - EyeWiki, Chloroquine - FDA prescribing information, side effects.

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  4. Keep chloroquine daily dose at 3 mg/kg/day and cumulative dose at 460 gm to reduce chances of retinopathy ; Keep hydroxychloroquine daily dose at 6.5mg/kg/day and cumulative dose at 1000gm to reduce chances of retinopathy ; Recognize that patients with renal failure are at unusually high risk of retinal toxicity

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    Dec 04, 2014 Hydroxychloroquine HCQ retinopathy can result in permanent vision loss. In early stages of HCQ retinopathy, patients are usually asymptomatic with preservation of visual acuity. We aspire that our review, in conjunction with the American Academy of. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11.

     
  5. Muenchen New Member

    : September 14, 2016 Chief complaint: Whirling and flashing lights A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. Rx Side Effects New Plaquenil Guidelines and More - American Academy. Effectiveness of Chloroquine and Hydroxychloroquine in. Plaquenil Uses, Dosage & Side Effects -
     
  6. ShuStr1k Guest

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Plaquenil - Plaquenil Side Effects on Your Eyes and Vision Plaquenil Hydroxychloroquine MyLupusTeam
     
  7. DrCoolMov XenForo Moderator

    Hydroxychloroquine-induced Hyperpigmentation of the Skin. Division of Rheumatology, Department of Internal Medicine, and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy.

    Skin Discoloration and Plaquenil - Arthritis Information
     
  8. Unic Guest

    Methotrexate and hydroxychloroquine combination therapy in. Indian Journal of Rheumatology 2008 September Original Article Volume 3, Number 3; pp. 93–97 Methotrexate and hydroxychloroquine combination therapy in chronic chikungunya arthritis a 16 week study S Pandya ABSTRACT Objective To study the clinical profile of patients of chronic chikungunya arthritis presenting to a rheumatology OPD in the Western part of India and to judge the treatment response to the disease modifying drugs methotrexate and hydroxychloroquine used to treat them.

    Persistent Arthralgia Associated with Chikungunya Virus Outbreak, US.