Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Obgyn plaquenil lupus Imodium plaquenil Retinal toxicity from chloroquine apre-19 cells Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Hydroxychloroquine skin discoloration Hydroxychloroquine-related skin discoloration CMAJ, Skin Discoloration and Plaquenil • Johns Hopkins Arthritis. When does plaquenil start workingAlternative meds than plaquenilMap of chloroquine resistant malariaPlaquenil false positive thc May 21, 2010 I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Plaquenil & skin discoloration -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Skin Discoloration and Plaquenil - Arthritis Information. One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins. Age of people who have Skin discoloration - bluish when taking Hydroxychloroquine sulfate * 0-1 0.0 %. 2-9 0.0 %. 10-19 23.08 %. 20-29 0.0 %. 30-39 7.69 %. 40-49 15.38 %. 50-59 7.69 %. 60+ 46.15 %. The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced pigmentation.