Chloroquine from quinine

Discussion in 'Canadian Online Pharmacy' started by Buryat, 23-Feb-2020.

  1. Drug New Member

    Chloroquine from quinine


    The tree is most commonly found in South America, Central America, the islands of the Caribbean, and parts of the western coast of Africa. Quinine was originally developed as a medicine to fight malaria.

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    Quinine is a bitter compound that comes from the bark of the cinchona tree. The tree is most commonly found in South America, Central America, the islands of the Caribbean, and parts of the. Quinine is an antimalarial drug which is made from Cinchona bark. The mode of action of quinine is similar to chloroquine. For the first time, the effects of quinine on the hexokinase activity of Plasmodium berghei P. berghei were reported by Fraser and Kermack in 1957. Chloroquine is the synthetic version of the natural quinine – i just wonder if quinine could have the same impact on coronovirus. Quinine is on WHO`s list of accepted antimarial drugs – like choroquine.

    Quinine, when found in small doses in tonic water, is safe to consume. It was crucial in reducing the death rate of workers building the Panama Canal in the early 20 century.

    Chloroquine from quinine

    Chloroquine - Wikipedia, Comparative study of chloroquine and quinine on malaria.

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  4. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

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    Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice. Quinine, chloroquine and mefloquine are positively charged under physiological conditions, and so binding in the channel should be influenced by changes in the membrane holding potential. Comparison of the quinine and chloroquine inhibition curves at −60 and +40 mV showed that they were indistinguishable. This includes chloroquine, halofantrine, and mefloquine. Avoid using antacids without your doctor's advice. Use only the type of antacid your doctor recommends. Some antacids can make it harder for your body to absorb quinine. Quinine may cause blurred vision and may impair your thinking or reactions.

     
  5. Bobot Well-Known Member

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  6. iGeX Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Compare Primaquine vs Chloroquine - Primaquine in vivax malaria an update and review on. Primaquine for Prevention of Malaria in Travelers Clinical.
     
  7. Petya007 User

    Recommendations on Screening for Chloroquine and Hydroxychloroquine. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools.

    Spectral-Domain Optical Coherence Tomography and Adaptive.