Please review the following URL and make sure that it is spelled correctly. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Is chloroquine safe in first trimester of pregnancy Hydroxychloroquine dose calculator Im experienceing the same thing as Allie. I have been on Plaquenil for a year and a half and im losing hair like crazy as well. My Rheumatologist just recently switched my med to Prednisone but i cant really see any changes yet. I believe the Plaquenil does have some kind of affect with hair loss. I will see what the eye doctor says and do more research. I think I'm going to try Monat hair system of shampoos, conditioners and scalp treatment I have seen a lot of great results with people with other forms of alopecia. I know it won't grow back what I'm lost but I'm hoping it stops it from getting worse. Last resort would be Plaquenil Hydroxychloroquine Plaquenil is a slow acting drug. It can take up to 8 weeks or more before the medication really starts to have an effect and actually help an individual using the drug. Because hydroxychloroquine is so delayed in its onset, I usually give it 4-6 months before really deciding if it is working. and sometimes even longer. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Incidence of alopecia with plaquenil Plaquenil and hairloss - HealthBoards, Thoughts on Plaquenil. - Alopecia World Hydroxychloroquine mode of actionUrinary side effects of hydroxychloroquinePlaquenil how does it workChloroquine autophagy lysosomeFolic acid and plaquenil Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known Hydroxychloroquine Side Effects Common, Severe, Long Term.. Hydroxychloroquine Plaquenil for Cicatricial Alopecia.. Lichen planopilaris Genetic and Rare Diseases.. Lichen planopilaris is a frequent presentation of primary cicatricial alopecia. Scalp distribution characterizes the main clinical presentations classic lichen planopilaris, frontal fibrosing alopecia and Graham-Little Piccardi-Lassueur Syndrome GLPLS. Description. Frontal fibrosing alopecia FFA is a form of lichen planopilaris that is characterized primarily by slowly progressive hair loss and scarring on the scalp near the some cases, the eyebrows, eye lashes and/or other parts of the body may be involved, as well. Although it has been suggested that FFA may be due to hormonal changes or an autoimmune response, the exact cause of this. Plaquenil is not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil is not recommended for the treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified.