Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil dosage by weight What are the side effects of the medication plaquenil Plaquenil hot flashes This apparently resulted in overdosing of thin patients. Thus, the patient’s real weight is now recommended as the basis for calculating the daily dose per weight in kg. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. There are risk factors which may increase the likelihood of an individual in developing symptoms of Plaquenil toxicity 1. Dosage. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil maculopathy dose Retinal Physician - Hydroxychloroquine Maculopathy An Update., Plaquenil Hydroxychloroquine - Side Effects, Dosage. Pool chloroquine tabletUronema chloroquine phosphateHow often is plaquenil takenWhat is the generic name for plaquenil A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Hydroxychloroquine Plaquenil Toxicity and.. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Calculates maximum daily dose of hydroxychloroquine to reduce risk of retinopathy. Favorite. IMPORTANT. This calculator is for double-checking hydroxychloroquine dosing, and should NOT be used as the primary means for ordering. enter current daily dose of hydroxychloroquine to determine if dose is too high. mg. Result Please fill out. Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment.