Just google does low dose naltrexone cause a herxheimer's reaction and I am sure you will find a lot of info. Did you have your med compounded from pure naltrexone powder or from ground up 50 mg Revia/generic equivalent? Here is how it applies to AP https://en.wikipedia.org/wiki/Type_III_hypersensitivity https://chronicillnessrecovery.org/index.php? Hi, Boise CGM- Can you please describe the "awful"? Happy to help if you can provide a few key details. Hydroxychloroquine temporal arteritis Doses of hydroxychloroquine Chloroquine vs chloroform Plaquenil macular toxicity oct From SilverColloids. The Herxheimer Reaction is a short-term from days to a few weeks detoxification reaction in the body. As the body detoxifies, it is not uncommon to experience flu-like symptoms including headache, joint and muscle pain, body aches, sore throat, general malaise, sweating, chills, nausea or other symptoms. Got off of it and I feel back to normal. My Lupus is mild so I'm going the holistic route. Plant based diet, acupuncture, juicing. I feel good and will take minor aches and fatigue any day than being on plaquenil. Beware! Do your research before accepting a lab created Rx from Dr.s. Mg twice daily. I didn’t feel too bad but a huge bout of stress made my symptoms worse. I then started methotrexate in addition to plaquenil. My rheumatologist suggested once daily Plaquenil and that seemed okay. After a while he said I coujd stop it as he was not sure if it was working. He's excellent, open-minded, and in my opinion quite brilliant - and had the following comment when I asked him about LDN in an email. Kk I've quoted my scleroderma specialist on LDN here before, but will copy and paste it again. Will i feel worse before i feel better on plaquenil How long until Hydroxychloroquine takes effect - LUPUS UK, Plaquenil Drug and Medication User Reviews on RxList Chloroquine syntheticHydroxychloroquine autophagyChloroquine phosphate tablets 500mgTurmeric and plaquenil Mar 14, 2017 I do believe that this is a herxing type reaction. I stayed very hydrated yesterday, and took 1500mg of L-glutamine last night before bed along with tylenol and my 1.5 mg of LDN. Wow, what a difference! I slept well, had none of the extreme swelling and pain that I did have the night and day before, and today I feel pretty good! LDN. can you feel worse before you get better.. Plaquenil Reviews & Ratings Page 2 at. Plaquenil Reviews & Ratings at. Thanks for the replies,yep,self-induced flare,I think. I couldn't help being a numpty because I felt so good blush I just wondered if Plaquenil made you feel worse rather than better at the start like antibiotics can sometimes. Hello friends, I take my Plaquenil in the morning with breakfast. I feel very shaky, dizzy and just off all day. Does anyone take it at night? Will it keep me up? Why do I have to take it in the morning. Sep 19, 2010 I do remember it took about 8 weeks before I noticed any difference at all. At three months I saw a big difference, and after six months, I am see a lot of difference. Before taking Plaquenil, I could barely walk. Everyone is different, so if a med is making you feel worse, I think you should let your doctor know and consider trying something else.