Chloroquine diphosphate autophagy

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  1. Gqiwoven Well-Known Member

    Chloroquine diphosphate autophagy


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors TLRs. Chloroquine diphosphate is used as an antimalarial drug and also functions to increase sensitivity of tumor cells to radiation and chemotherapy via inducing autophagy 1. Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-cancer cells proliferation or metastasis 2. Chloroquine phosphate 50-63-5 is an antimalarial drug. Inhibits autophagy in a variety of cell lines 1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer 2. Eliminates cancer stem cells via deregulation of Jak2 and DNMT1 3.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine diphosphate autophagy

    Autophagy inhibitor chloroquine induces apoptosis of cholangiocarcinoma., APExBIO - Chloroquine diphosphateAntimalarial drugCAS# 50-63-5

  2. What is chloroquine used for
  3. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

    • Chloroquine - Wikipedia.
    • Chloroquine phosphate autophagy inhibitor.
    • Chloroquine inhibits autophagic flux by decreasing..

    Chloroquine diphosphate, apoptosis and autophagy inhibitor CAS 50-63-5, with 98% purity. Water soluble compound. Join researchers using our high quality biochemicals. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH.

     
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  5. marelos Well-Known Member

    Selected from data included with permission and copyrighted by First Databank, Inc. Hydroxychloroquine MedlinePlus Drug Information Is Gabapentin Safe to Take? Plaquenil & other drug interactions ? Lupus Forums at.
     
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    Chloroquine Side Effects Common, Severe, Long Term -
     
  7. Cody Moderator

    Chloroquine Uses, Side Effects & Warnings - Nov 25, 2019 Malaria is more likely to cause death in a pregnant woman. If you are pregnant, talk with your doctor about the risks of traveling to areas where malaria is common. Chloroquine can pass into breast milk and may cause side effects in the nursing baby.

    Chloroquine resistant vivax malaria in a pregnant woman on.