They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Hydroxychloroquine sulfate and prednisone together Side effects of chloroquine malaria pills Chloroquine 250 mg side effects Take plaquenil while healing leaky gut Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Drugs that can Harm the Immune System and Lungs. The flu is rarely deadly. It's flu that becomes pneumonia that kills. Prescription and over-the-counter drugs should be seriously considered on the list of things that could potentially make people more susceptible to having a flu that morphs into a deadly pneumonia. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does plaquenil suppress the immune system Do either hydroxychol/Plaquenil put you at risk for greater., Drugs that can Harm the Immune System and Lungs What is blood test for plaquenil liver damageDoes hydroxychloroquine cause human birth defectsPlaquenil maculopathy mechanisms Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree, because ‘overactivity’ of the immune system is what drives the illness. Methotrexate Does it weaken my immune system?. Hydroxychloroquine Plaquenil. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. I'm not a healthcare provider, but I do take Plaquenil and just found out from another user of it that it does suppress the immune system. I didn't know that when I started taking it for Sjogren's in November 2011. Thomas says he understands people’s concerns about the drug’s potential for toxicity. “But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system.